Answers to Nephrology : Challenging Cases Update in Internal Medicine – 2016
نویسنده
چکیده
1. A. The sodium-glucose transporter-2 (SGLT-2) inhibitors, empaglifloxin (Jardiance®), dapagliflozin (Farxiga®), and canagliflozin (Invokana®) inhibit proximal tubular glucose reabsorption resulting in renal glucosuria. These drugs can cause weight loss, natriuresis with volume depletion, hypotension, bacterial or fungal UTI, and ketoacidosis even in Type 2 diabetics. Ketoacidosis is more likely with fasting (or alcohol intake) as occurred in this patient. The increased anion gap metabolic acidosis would not be present in RTA, hyperventilation or UTI (without a septic picture).
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